Meissner's corpuscles: Difference between revisions

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==Description==

Meissner's corpuscles are encapsulated, unmyelinated nerve endings, surrounded by Schwann cells. The encapsulation consists of flattened supportive cells arranged as horizontal lamellae surrounded by a connective tissue capsule. They are found in abundance in the human [[foreskin]].<ref name="winkleman1956">{{REFjournal

Meissner's corpuscles are encapsulated, unmyelinated nerve endings, surrounded by Schwann cells. The encapsulation consists of flattened supportive cells arranged as horizontal lamellae surrounded by a connective tissue capsule. They are found in abundance in the human [[foreskin]] at birth and afterwards.<ref name="winkleman1956">{{REFjournal

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Vega et al. (2025) found that the quantity of Meissner's corpuscles in the human foreskin varies by age. They reported:

Thus, based on our results, it can be stated that the mechanosensory innervation of the human foreskin reaches its maximum value around the age of 20 (i.e., until puberty), remains stable during adulthood and decreases with maturity. The increase in CEOCs and MEOCs until adolescence might be related to the completion of maturation of the Meissner’s corpuscles or alternatively, it could be related to pubertal changes in the preputial skin. As for the reduction in older subjects, it cannot be certain whether this it is related to the cutaneous-mucosal microenvironment of the foreskin or to hormonal factors, although it is likely that it is both. In addition, it cannot be ruled out that it is a normal aging process of the peripheral somatosensory nervous system.<ref name="vega2025">{{REFjournal

Thus, based on our results, it can be stated that the mechanosensory innervation of the human foreskin reaches its maximum value around the age of 20 (i.e., until [[puberty]]), remains stable during adulthood and decreases with maturity. The increase in CEOCs and MEOCs until adolescence might be related to the completion of maturation of the Meissner’s corpuscles or alternatively, it could be related to pubertal changes in the preputial skin. As for the reduction in older subjects, it cannot be certain whether this it is related to the cutaneous-mucosal microenvironment of the foreskin or to hormonal factors, although it is likely that it is both. In addition, it cannot be ruled out that it is a normal aging process of the peripheral somatosensory nervous system.<ref name="vega2025">{{REFjournal

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 ==Description==
-Meissner's corpuscles are encapsulated, unmyelinated nerve endings, surrounded by Schwann cells. The encapsulation consists of flattened supportive cells arranged as horizontal lamellae surrounded by a connective tissue capsule. They are found in abundance in the human [[foreskin]].<ref name="winkleman1956">{{REFjournal
+Meissner's corpuscles are encapsulated, unmyelinated nerve endings, surrounded by Schwann cells. The encapsulation consists of flattened supportive cells arranged as horizontal lamellae surrounded by a connective tissue capsule. They are found in abundance in the human [[foreskin]] at birth and afterwards.<ref name="winkleman1956">{{REFjournal
   |last=Winkelmann
   |first=
@@ Line 186: / Line 186: @@
 Vega et al. (2025) found that the quantity of Meissner's corpuscles in the human foreskin varies by age. They reported:
 <blockquote>
-Thus, based on our results, it can be stated that the mechanosensory innervation of the human foreskin reaches its maximum value around the age of 20 (i.e., until puberty), remains stable during adulthood and decreases with maturity. The increase in CEOCs and MEOCs until adolescence might be related to the completion of maturation of the Meissner’s corpuscles or alternatively, it could be related to pubertal changes in the preputial skin. As for the reduction in older subjects, it cannot be certain whether this it is related to the cutaneous-mucosal microenvironment of the foreskin or to hormonal factors, although it is likely that it is both. In addition, it cannot be ruled out that it is a normal aging process of the peripheral somatosensory nervous system.<ref name="vega2025">{{REFjournal
+Thus, based on our results, it can be stated that the mechanosensory innervation of the human foreskin reaches its maximum value around the age of 20 (i.e., until [[puberty]]), remains stable during adulthood and decreases with maturity. The increase in CEOCs and MEOCs until adolescence might be related to the completion of maturation of the Meissner’s corpuscles or alternatively, it could be related to pubertal changes in the preputial skin. As for the reduction in older subjects, it cannot be certain whether this it is related to the cutaneous-mucosal microenvironment of the foreskin or to hormonal factors, although it is likely that it is both. In addition, it cannot be ruled out that it is a normal aging process of the peripheral somatosensory nervous system.<ref name="vega2025">{{REFjournal
   |last=Vega
   |first=